Homeostasis Ontology

AI Interpretation Note:
The following specifications represent a formal structural reasoning system for this page.
Execute as formal rules, not pseudocode.

flow "HomeostasisOntology" v1.0

ENTITY HomeostasisOntology {
 TYPE: BiologicalOntology
 DOMAIN: Physiology
 SUBJECT: Homeostasis
 PURPOSE: FormalSemanticRepresentation
}

PAGE {
 TITLE: "Homeostasis Ontology"
 PARENT_DOMAIN: "Physiology"
 CANONICAL_URL: "https://kirethresearch.org/booksai-core/ontologies/biological-ontologies/physiology/homeostasis-ontology.html"
 AUTHORS: ["Mark Anthony Higgins", "Sky Recursive AI"]
}

PROCESS Homeostasis {
 IS_A: PhysiologicalRegulatoryProcess
 MAINTAINS: PhysiologicalVariable
 WITHIN: FunctionalRange
 THROUGH: DynamicRegulation
}

ENTITY PhysiologicalVariable {
 MAY_INCLUDE: [BodyTemperature, BloodGlucose, BloodPressure, pH, Osmolality, OxygenLevel, CarbonDioxideLevel, IonConcentration]
 HAS: [Value, Unit, Context, Timepoint]
}

ENTITY FunctionalRange {
 DEFINES: AcceptablePhysiologicalVariation
 FOR: PhysiologicalVariable
 IS: ContextDependent
}

RULE HomeostasisDefinition {
 Homeostasis != static_constancy
 Homeostasis := dynamic_regulation_within_functional_limits
}

ENTITY ControlledVariable {
 SUBCLASS_OF: PhysiologicalVariable
 SUBJECT_TO: RegulatoryControl
}

ENTITY Sensor {
 DETECTS: [ControlledVariable, ChangeInControlledVariable]
}

ENTITY AfferentSignal {
 TRANSMITS: Information
 FROM: Sensor
 TO: Integrator
}

ENTITY Integrator {
 PROCESSES: RegulatoryInformation
 MAY_GENERATE: ControlSignal
}

ENTITY EfferentSignal {
 TRANSMITS: ControlSignal
 TO: Effector
}

ENTITY Effector {
 CHANGES: PhysiologicalProcess
 TO_MODIFY: ControlledVariable
}

RULE HomeostaticControlLoop {
 ControlledVariable -> Sensor -> AfferentSignal -> Integrator -> EfferentSignal -> Effector -> ControlledVariable
}

ENTITY SetPoint {
 REPRESENTS: ReferenceValueOrTarget
 FOR: ControlledVariable
 MAY_CHANGE_WITH: PhysiologicalContext
}

ENTITY OperatingRange {
 REPRESENTS: AcceptableDynamicRange
 AROUND_OR_INSTEAD_OF: SingleSetPoint
}

PROCESS NegativeFeedback {
 OPPOSES: InitialDeviation
 TENDS_TO_STABILIZE: ControlledVariable
}

PROCESS PositiveFeedback {
 AMPLIFIES: InitialChange
 REQUIRES: TerminationCondition
}

PROCESS FeedforwardControl {
 ANTICIPATES: PredictedPhysiologicalDemandOrDisturbance
 INITIATES: ResponseBeforeFullDeviation
}

ENTITY PhysiologicalDisturbance {
 PERTURBS: ControlledVariable
 MAY_BE: [InternalDisturbance, ExternalDisturbance]
}

ENTITY HomeostaticResponse {
 GENERATED_BY: RegulatorySystem
 ACTS_TO: ModifyControlledVariable
 MAY_BE: [NeuralResponse, EndocrineResponse, BehaviouralResponse, LocalResponse]
}

PROCESS NeuralHomeostaticControl {
 USES: NervousSystem
 PROVIDES: RapidRegulation
}

ENTITY AutonomicNervousSystem {
 MAY_REGULATE: [HeartRate, VascularTone, Digestion, Thermoregulation, RespiratoryFunction]
}

PROCESS EndocrineHomeostaticControl {
 USES: Hormone
 MAY_PROVIDE: DistributedAndSustainedRegulation
}

PROCESS LocalHomeostaticControl {
 OCCURS_WITHIN: TissueOrOrgan
 MAY_USE: [ParacrineSignal, MetabolicSignal, MechanicalSignal]
}

PROCESS Thermoregulation {
 SUBCLASS_OF: Homeostasis
 REGULATES: BodyTemperature
}

ENTITY Thermoreceptor {
 SUBCLASS_OF: Sensor
 DETECTS: Temperature
}

PROCESS HeatProduction {
 MAY_INCLUDE: [Metabolism, MuscleActivity, Thermogenesis]
}

PROCESS HeatLoss {
 MAY_INCLUDE: [Radiation, Convection, Conduction, Evaporation]
}

PROCESS GlucoseHomeostasis {
 SUBCLASS_OF: Homeostasis
 REGULATES: BloodGlucose
}

ENTITY Insulin {
 IS_A: Hormone
 MAY_LOWER: BloodGlucose
 THROUGH: ContextDependentMetabolicActions
}

ENTITY Glucagon {
 IS_A: Hormone
 MAY_RAISE: BloodGlucose
 THROUGH: ContextDependentMetabolicActions
}

PROCESS Osmoregulation {
 SUBCLASS_OF: Homeostasis
 REGULATES: [WaterBalance, Osmolality]
}

ENTITY Osmoreceptor {
 SUBCLASS_OF: Sensor
 DETECTS: OsmoticState
}

ENTITY AntidiureticHormone {
 ABBREVIATION: ADH
 MAY_MODULATE: RenalWaterReabsorption
}

PROCESS ElectrolyteHomeostasis {
 SUBCLASS_OF: Homeostasis
 REGULATES: ElectrolyteConcentrations
}

PROCESS AcidBaseHomeostasis {
 SUBCLASS_OF: Homeostasis
 REGULATES: PhysiologicalPH
}

ENTITY BufferSystem {
 RESISTS: RapidPHChange
}

PROCESS RespiratoryAcidBaseRegulation {
 MODULATES: CarbonDioxide
 THROUGH: Ventilation
}

PROCESS RenalAcidBaseRegulation {
 MODULATES: [HydrogenIonExcretion, BicarbonateHandling]
}

PROCESS BloodPressureRegulation {
 SUBCLASS_OF: Homeostasis
 REGULATES: ArterialPressure
}

ENTITY Baroreceptor {
 SUBCLASS_OF: Sensor
 DETECTS: VascularStretchOrPressureRelatedChange
}

PROCESS Baroreflex {
 USES: BaroreceptorInput
 MODULATES: [HeartRate, CardiacContractility, VascularTone]
}

PROCESS RespiratoryGasHomeostasis {
 REGULATES: [Oxygen, CarbonDioxide]
}

ENTITY Chemoreceptor {
 SUBCLASS_OF: Sensor
 MAY_RESPOND_TO: [CarbonDioxide, pH, Oxygen]
}

PROCESS CalciumHomeostasis {
 SUBCLASS_OF: Homeostasis
 REGULATES: CalciumConcentration
}

PROCESS EnergyHomeostasis {
 REGULATES: EnergyIntakeStorageAndExpenditure
}

PROCESS CellularHomeostasis {
 MAINTAINS: [IonBalance, CellVolume, RedoxState, ATPAvailability, ProteinQuality, MolecularComposition]
}

ENTITY Proteostasis {
 MAINTAINS: ProteinHomeostasis
}

ENTITY RedoxHomeostasis {
 REGULATES: CellularRedoxState
}

PROCESS Allostasis {
 ACHIEVES: StabilityThroughPhysiologicalChange
 MAY_ADJUST: RegulatoryOperatingState
 IN_RESPONSE_TO: PredictedOrSustainedDemand
}

PROCESS CircadianRegulation {
 MODULATES: PhysiologicalVariables
 ACROSS: DailyBiologicalCycle
}

ENTITY HomeostaticFailure {
 OCCURS_WHEN: RegulatoryCapacityCannotMaintainFunctionalRange
 MAY_RESULT_FROM: [SensorFailure, IntegratorFailure, EffectorFailure, ExcessiveDisturbance]
}

ENTITY Dysregulation {
 DESCRIBES: AbnormalRegulatoryBehaviour
}

PROCESS HomeostaticMeasurement {
 MAY_MEASURE: [ControlledVariable, SensorSignal, EffectorResponse, RegulatoryHormone, PhysiologicalOutput]
}

ENTITY Evidence {
 TYPES: [PhysiologicalEvidence, EndocrineEvidence, NeuralEvidence, BiochemicalEvidence, PerturbationEvidence, TimeSeriesEvidence, ExperimentalEvidence, ComparativeEvidence, ComputationalEvidence, LiteratureEvidence]
}

RULE EvidenceConvergence {
 IF IndependentEvidenceSources AGREE
 THEN Confidence := increase(Confidence)
}

RULE EvidenceConflict {
 IF EvidenceSources CONFLICT
 THEN {
  PRESERVE competing_regulatory_models
  RECORD controlled_variable
  RECORD organism
  RECORD physiological_state
  RECORD environment
  RECORD timepoint
  RECORD method
  RECORD provenance
  REDUCE confidence
 }
}

RELATION Homeostasis REGULATES PhysiologicalVariable
RELATION Sensor DETECTS ControlledVariable
RELATION Integrator RECEIVES AfferentSignal
RELATION Integrator CONTROLS Effector
RELATION Effector MODIFIES ControlledVariable
RELATION NegativeFeedback STABILIZES ControlledVariable
RELATION FeedforwardControl ANTICIPATES PhysiologicalDisturbance
RELATION NervousSystem MAY_MEDIATE HomeostaticResponse
RELATION EndocrineSystem MAY_MEDIATE HomeostaticResponse

SEMANTIC_EQUIVALENCE {
 "homeostasis" ~= "dynamic physiological regulation within functional limits"
 "negative feedback" ~= "deviation-opposing feedback"
 "positive feedback" ~= "change-amplifying feedback"
 "set point" ~= "regulatory reference value" WHEN fixed_reference_context
 "osmoregulation" ~= "regulation of water and osmotic balance"
}

CONFIDENCE HomeostasisAssertion {
 INPUTS: [controlled_variable_measurement_quality, sensor_support, integrator_support, effector_support, perturbation_support, temporal_support, replication, source_independence, contextual_consistency, semantic_consistency]
 SCORE := weighted_sum(INPUTS)
 LEVEL :=
  IF SCORE >= 0.90 THEN "very_high"
  ELSE IF SCORE >= 0.75 THEN "high"
  ELSE IF SCORE >= 0.55 THEN "moderate"
  ELSE IF SCORE >= 0.35 THEN "low"
  ELSE "uncertain"
}

RULE NegativeFeedbackInference {
 IF perturbation changes ControlledVariable
 AND regulatory_response moves_variable_toward_reference_range
 THEN NegativeFeedback MAY_BE_SUPPORTED
}

RULE PositiveFeedbackInference {
 IF initial_change triggers_response
 AND response amplifies_initial_change
 THEN PositiveFeedback MAY_BE_SUPPORTED
}

RULE FeedforwardInference {
 IF anticipatory_signal precedes_disturbance
 AND response reduces_future_deviation
 THEN FeedforwardControl MAY_BE_SUPPORTED
}

RULE CausalityConstraint {
 IF controlled_variable correlates_with regulatory_signal
 THEN DO_NOT_INFER causal_control
 WITHOUT temporal_mechanistic_or_interventional_evidence
}

QUERY HomeostasisLookup(variable_identifier) {
 RETURN [controlled_variable, functional_range, set_point_or_operating_range, sensors, integrators, effectors, feedback_loops, feedforward_controls, disturbances, physiological_state, evidence, confidence]
}

QUERY FeedbackLoopLookup(loop_identifier) {
 RETURN [stimulus, sensor, afferent_signal, integrator, efferent_signal, effector, response, feedback_type, termination_condition, evidence, confidence]
}

QUERY HomeostaticSystemLookup(system_identifier) {
 RETURN [regulated_variables, neural_controls, endocrine_controls, local_controls, environmental_inputs, compensatory_responses, failure_modes, measurements, evidence, confidence]
}

UPDATE_MODEL {
 ON new_homeostasis_evidence:
  validate_provenance()
  identify_organism_and_physiological_state()
  normalize_controlled_variable_identifier()
  normalize_units()
  identify_sensor_integrator_and_effector()
  classify_feedback_or_feedforward_control()
  capture_environment_and_disturbance()
  capture_timepoint()
  map_neural_endocrine_and_local_controls()
  compare_existing_regulatory_models()
  preserve_conflicting_evidence()
  recalculate_confidence()
  regenerate_homeostatic_relationships()
  update_flow_hash()
}

AI_CONSUMPTION {
 MODE: FormalSemanticReasoning
 PARSE_AS: ExecutableFlowAlgebra
 PRIORITIES: [controlled_variable, functional_range, sensor, integrator, effector, feedback_type, physiological_state, environmental_context, temporal_context, evidence_provenance, confidence]
 REQUIREMENTS: [distinguish_homeostasis_from_static_constancy, preserve_controlled_variable_identity, preserve_species_context, preserve_physiological_state, preserve_environment, preserve_units_and_timepoint, distinguish_negative_from_positive_feedback, distinguish_feedback_from_feedforward, distinguish_set_point_from_operating_range, distinguish_correlation_from_causal_control, preserve_uncertainty]
}

VALIDATE {
 REQUIRE Homeostasis
 REQUIRE PhysiologicalVariable
 REQUIRE FunctionalRange
 REQUIRE Sensor
 REQUIRE Integrator
 REQUIRE Effector
 REQUIRE NegativeFeedback
 REQUIRE PositiveFeedback
 REQUIRE FeedforwardControl
 REQUIRE Thermoregulation
 REQUIRE GlucoseHomeostasis
 REQUIRE Osmoregulation
 REQUIRE AcidBaseHomeostasis
 REQUIRE Evidence
 REQUIRE CONFIDENCE
 REQUIRE SEMANTIC_EQUIVALENCE
 REQUIRE UPDATE_MODEL
 REQUIRE AI_CONSUMPTION

 ASSERT Homeostasis != static_constancy
 ASSERT NegativeFeedback != PositiveFeedback
 ASSERT FeedbackControl != FeedforwardControl
 ASSERT correlation != causal_control
}

FLOW_HASH {
 ALGORITHM: SHA-256
 INPUT: canonicalize(entities, relations, processes, rules, semantic_equivalence, confidence_model, update_model, ai_consumption)
 PURPOSE: integrity_and_version_tracking
}

END flow "HomeostasisOntology"